Show that fibromyalgia is not an imaginary disease

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They have often felt misunderstood. Or worse, accused of simulating an ailment. But now science proves them right. And it is that medical geneticists have found that fibromyalgia – a disease that hitherto regarded generally as a disorder psychological of somatization – is a pathology of origin neurological result of neurochemical imbalances in the central nervous system.

Thanks to a study conducted with 3,000 people-of which two – thirds of them were suffering from fibromyalgia and chronically fatigue has been determined that there are 90 polymorphisms in the DNA of patients that affect the immune and nervous system. This research “represents the only evidence of genetic markers associated with fibromyalgia”, say the authors, Genomic Genetics International (GGI).

“There is sufficient evidence to consider this condition as a disease of organic basis, provided it is properly diagnosed,” he told La Vanguardia Dr. José Ignacio Lao, director of GGI. The problem experienced by patients suffering from this condition is that your immune system tends to respond in an exaggerated way. “The first reaction of this system when we agrede something is inflammation. But fibromyalgia sufferers this reaction is much more intense and prolonged in time, which becomes harmful, “argues Lao.

There is sufficient evidence to consider fibromyalgia as a disease of organic basis, provided it is properly diagnosed


Geneticists have discovered the interaction of two genes that explain why the painful stimulus is stronger in patients with fibromyalgia. There is even another receptor gene -called mu opioid – “that makes these people not only perceive more physical pain, but also the psychic” wields the director of GGI. “A social rejection or a ruptured partner leaves them deeper than other people without this genetic variant footprint , ” he adds.

The beginning of the end of stigma?

Although fibromyalgia was identified as a disease by the World Health Organization (WHO) in 1992 -including within reumatismos in the International Classification of disease-, many people who suffer from it have had to endure unreasonably hard stigma of being simulating, in the eyes of others, an ailment. “The accused him of whiners, vague, but now we have an explanation at the level of biological markers of everything that happens,” said Lao.

Beyond the pain suffered by fibromyalgia – “at all levels, not only skeletal muscle”, points out these are affected Lao ability to maintain brain chemical balance. Suffer from a trend deficit of neurotransmitters-the brain chemicals responsible for transmitting nervous hence within the pathology has an inclination to memory loss (early cognitive impairment), depression and sleep disorders, lack serotonin. “Even stressful for them trigger outbreaks situations,” recalls the director of GGI.

They accused them of whiners, vague, but now we have an explanation at the level of biological markers of everything that happens


Although today fibromyalgia has no medical remedy, it is certain that there are many hopes in the field of biotechnology so that it can find a definitive solution. Genetics is developing new therapeutic agents. “One of them is the RNA interference,” said Lao. “They are small molecules which specifically block is intended gene patients have more expressed” added.

Genetics and allows individualized treatment to know, in other things, how patients metabolize anti-inflammatories, such as ibuprofen, taking to minimize the effects of fibromyalgia, “and especially what is the effective and safe dose, which is what is really important, “Lao said. You can even do preventive medicine in families with a history. And in familiar environments where there is a case of fibromyalgia eightfold the likelihood that more cases appear, as the statistics show.

In Spain it is estimated that 2.4% of the population suffers from fibromyalgia

Even cases occur in children, but few, which already appears hypersensitivity. In fact, many people with the disease of older explain that children were hypersensitive to certain stimuli.

Thanks to all these new treatments a door to hope for those suffering from fibromyalgia opens. In Spain it is estimated that 2.4% of the population suffers.

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